การเปรียบเทียบผลของ CU 763-16-04 และ CU 763-15-13 ต่อการหดตัวของกล้ามเนื้อเรียบกระเพาะอาหารหนูขาวและผลของ CU 763-16-04 ต่อหลอดเลือดแดงใหญ่กระต่ายที่แยกจากกาย

Abstract

The effects of CU 763-16-04 and CU 763-15-13, of which main structure was acylamino pyridine and structure ally related to some synthetic K+-channel opener, on the smooth muscle contraction of isolated rat stomach, rabbit aorta, rat aorta and vasdeferens had been studied. CU 763-16-04 as well as CU 763-15-13 reduced the smooth muscle contractions of rat stomach, which induced by 5-HT, Ach, CaCl2 และ BaCl2 in high potassium depolarizing solution and TEA ; but less potent than papaverine. Pre-incubation with CU 763-16-04 reduced the smooth muscle contractions of rat stomach which induced by 5-HT in Ca2+-free krebs buffer. CU 763-16-04 as well as CU 763-15-13 reduced the smooth muscle contractions of rat aorta and vasdeferens, but CU 763-16-04 increased the smooth muscle contractions of rabbit aorta induced by 5-HT. CU 763-16-04 reduced the smooth muscle contractions of rat vasdeferens, of which different from CU 763-15-13 induced by NE. These results suggested that CU 763-16-04 and CU 763-15-13 produced non-specific relaxing effect on isolated smooth muscle. The mechanism of action of CU 763-16-04 and CU 763-15-13 may interfere with the release of intracellular calcium from SR and calcium movement through calcium channel, probably by opening K+-channel.