Boolean model for biochemical processes related To effect of cha in cancer cells

Abstract

Cancer is a group of diseases involving abnormal cell growth. In the present, cancer is one of the major diseases causing death annually. To inhibit cancer cells, several substances have been proposed and studied; for example, a compound namely a coumarin compound has been studied since it can inhibit cancer cells. However, the detailed biochemical processes explaining the effect of this substance is quite rare. Therefore, it is an important task to understand this effect in changing the biochemical pathways in more detail by mathematical methods. In this study, we construct Boolean model which includes apoptosis, calcium signaling pathway, and inflammation to explain the effect of a coumarin compound in cancer cells. Finally, the model will be used to explain the signaling processes and identify more new potential targets in treating cancers.