Characteristics of bacterial cellulose film synthesized by acetobacter xylinum containing garcinia mangostana extract

Abstract

Many kinds of polymeric materials recently have been applied in biomedical researches. Bacterial cellulose (BC) is the one of biomaterials, which has been interested for medical application because of its unique properties. In order to improve their biological properties, the modifications by means of impregnation of the extract of Garcinia mangostana fruit rind into the BC film by using 2.5-10.0%w/v aqueous extract and 0.25-1.00%v/v ethanolic extract were investigated. From FT-IR analysis, the interaction between BC functional groups and mangosteen extract compounds, which absorbed into the BC film, was indicated. The tensile strength and elongation at break of the BC films with the aqueous extract (BCWM) were decreased by increasing extract concentration, whereas those of the BC films with the ethanolic extract (BCEM) were increased. The water absorption capacity and water vapor transmission rate of BCWM were increased due to the more hydrophilic property after adding G. mangostana aqueous extract. Both BCWM and BCEM films exhibited antibacterial and antifungal effects on the growths of Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes and Aspergillus niger, whereas only BCWM films exhibited antibacterial effect against Escherichia coli. In addition, the BCWM and BCEM films exhibited cytotoxic effects on B16 melanoma cells. Therefore, the modified BC films containing G. mangostana extracts exhibit advantageous properties for many possible medical applications.