Chemical constituents from the roots of Cratoxylum cochinchinense

Abstract

The phytochemical investigation of the CH2Cl2 extract from the roots of Cratoxylum cochinchinense led to the isolation of four new xanthone derivatives, namely cratochinone A-D (1-4), along with sixteen known xanthones (5-20). Their structures were characterized by spectroscopic methods, especially spectroscopic data (1D and 2D NMR) as well as comparison with those reported in the literature for known xanthones. Moreover, all isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and Hep G2 cell lines). Compounds 2, 7, and 9 showed significant cytotoxic effects against all cell lines with IC₅₀ values in the range of 0.91–9.93 μM, while 12 exhibited cytotoxicity against the KB, HeLa S-3, and HT-29 cells with IC₅₀ values of 7.39, 6.07, and 8.11 μM, respectively. Compound 14 exhibited cytotoxicity against both KB and HeLa S-3 cells with IC₅₀ values of 7.28 and 9.84 μM.